Robert Insall

ZizB , a novel RacGEF regulates development , cell motility and cytokinesis in Dictyostelium

A Rational for Using the Epicondylar Axis as the Reference for Femoral Component Rotation in Total Knee Arthroplasty

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WASP and SCAR/WAVE proteins: the drivers of actin assembly.

proteins: the drivers of actin assembly Alice Y. Pollitt1 and Robert H. Insall2,* 1Centre for Cardiovascular Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK 2Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, UK *Author for correspondence (e-mail: [email protected]...

Chemotaxis: TorC before You Akt…

Chemotaxis uses intertwined signalling pathways, each individually dispensable. Recent work shows that Dictyostelium PKB/Akt can be spatially regulated independently of phosphatidylinositol (3,4,5)-trisphosphate via phosphorylation by TOR complex 2, placing this complex at the hub of chemotaxis.

Actin-Based Motility: WAVE Regulatory Complex Structure Reopens Old SCARs

The SCAR/WAVE complex controls actin polymerization at the leading edges of moving cells, but its mechanism of regulation remains unclear. The recent determination of its crystal structure, and identification of the binding sites for upstream regulators, mean its workings can finally start to be revealed.